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KMID : 1103720070560020161
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Journal of the Korean Society of Radiology
2007 Volume.56 No. 2 p.161 ~ p.170
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Assessment of the Viable Fraction of Hepatocytes by Mangafodipir Trisodium Enhanced Functional MR Imaging: Preliminary Report in Animal Models
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Cho Soon-Koo
Jeon Yong-Sun
Lee Kyung-Hee
Seo Chang-Hae
Song Jang-Ho
Park In-Suh
Han Seung-Baik
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Abstract
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Purpose: We designed this study to evaluate the feasibility of using mangafodipir trisodium enhanced functional liver imaging (MT-FLI) for assessing the viable fraction of hepatocytes (VFH) in the liver.
Materials and Methods: We evaluated the change of VFH with using MT-FLI before and after inducing acute hepatic necrosis (AHN) with CCl4 in the liver of 15 beagle dogs. The MR imaging was performed on a 1.5T MRI unit with using the EFGRE-3D sequence (TR/TE=4.7/1.1 msec; flip angle: 20.0degree). We evaluated the linear dependence of the density of viable hepatocytes in AHN on the MR images as compared to that in the corresponding normal livers (DAHN/DN) on the VFH in their pathologic specimens, and the change of the VFH from the MT-FLI on that of the laboratory findings (AST, ALT, albumin, bilirubin, PT, ICG-R15) before and after AHN induction.
Results: The mean+/-SD of the VFH from the MT-FLI in AHN was 61.2+/-10.7% of that of the normal ones. The DAHN/DN showed strong positive linear dependence on the VFH in their pathologic specimens (?=.769, p<.05). The change of the VFH from MT-FLI showed high linear dependence on that of all the above-mentioned laboratory findings (?<-.933 or >.938, p<.05).
Conclusion: The MT-FLI seems to be a feasible method for measuring VFH in the liver.
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KEYWORD
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Liver, Liver function, Magnatic resonance(MR) volume measurement, Animals
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